| 1 | Sun 15 Feb | Castleford Tigers v Wigan Warriors | 15:00 | The OneBore Stadium |
| 2 | Sat 21 Feb | Toulouse Olympique v Castleford Tigers | 19:00 | Stade Ernest-Wallon |
| 3 | Fri 27 Feb | Castleford Tigers v Huddersfield Giants | 20:00 | The OneBore Stadium |
| 4 | Sun 8 Mar | Leeds Rhinos v Castleford Tigers | 15:00 | AMT Headingley Stadium |
| 5 | Sat 21 Mar | Warrington Wolves v Castleford Tigers | 15:00 | The Halliwell Jones Stadium |
| 6 | Thurs 26 Mar | Castleford Tigers v Bradford Bulls | 20:00 | The OneBore Stadium |
| 7 | Sun 5 Apr | Castleford Tigers v Wakefield Trinity | 15:00 | The OneBore Stadium |
| 8 | Sun 19 Apr | Wigan Warriors v Castleford Tigers | 15:00 | The Brick Community Stadium |
| 9 | Fri 24 Apr | Castleford Tigers v Hull FC | 20:00 | The OneBore Stadium |
| 10 | Thurs 30 Apr | Hull KR v Castleford Tigers | 20:00 | Sewell Group Craven Park |
| 11 | Sat 16 May | York Knights v Castleford Tigers | 15:00 | LNER Community Stadium |
| 12 | Sat 23 May | Castleford Tigers v St Helens | 15:00 | The OneBore Stadium |
| 13 | Fri 5 June | Castleford Tigers v Leigh Leopards | 20:00 | The OneBore Stadium |
| 14 | Sat 13 Jun | Catalans Dragons v Castleford Tigers | 19:00 | Stade Gilbert Brutus |
| 15 | Sat 20 Jun | Castleford Tigers v Toulouse Olympique | 20:00 | The OneBore Stadium |
| 16 | Fri 26 Jun | Castleford Tigers v York Knights | 20:00 | The OneBore Stadium |
| 17 | Sun 5 July | Wakefield Trinity v Castleford Tigers | TBC | Hill Dickinson Stadium |
| 18 | Sat 11 July | Leigh Leopards v Castleford Tigers | 15:00 | Progress With Unity Stadium |
| 19 | Sun 19 July | Castleford Tigers v Leeds Rhinos | 15:00 | The OneBore Stadium |
| 20 | Fri 24 July | Wakefield Trinity v Castleford Tigers | 20:00 | DIY Kitchens Stadium |
| 21 | Sat 1 Aug | Castleford Tigers v Warrington Wolves | 15:00 | The OneBore Stadium |
| 22 | Fri 7 Aug | Castleford Tigers v Hull KR | 20:00 | The OneBore Stadium |
| 23 | Fri 14 Aug | Hull FC v Castleford Tigers | 20:00 | MKM Stadium |
| 24 | Sat 22 Aug | St Helens v Castleford Tigers | 15:00 | BrewDog Stadium |
| 25 | Fri 28 Aug | Castleford Tigers v Catalans Dragons | 20:00 | The OneBore Stadium |
| 26 | Thurs 3 Sept | Bradford Bulls v Castleford Tigers | 20:00 | Bartercard Odsal Stadium |
| 27 | Fri 11 Sept | Huddersfield Giants v Castleford Tigers | 20:00 | Accu Stadium |
